Brown Launches Biomedical Innovation Fund to Speed up Medical Technology

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Brown Launches Biomedical Innovation Fund to Speed up Medical Technology

Robert Reenan studies ALS using fruit flies engineered to genetically model the human disease. PHOTO: Brown
Brown University has launched the Brown Biomedical Innovation Fund to speed up the school’s medical technologies and get them to market. The fund is the first program of Brown Biomedical Inc. and was created by Dr. Jack Elias, dean of medicine and biologic sciences. 

“Through this new innovation fund, we can help our teams of researchers advance promising discoveries toward marketable technologies so that they can realize their full potential. Moreover, this targeted program creates an environment that fosters faculty enterprise and provides real-life scientific and entrepreneurial experience to our students,” said Elias. 

The University also asked for faculty members to apply for the first Biomedical Innovation Fund grants of up to $100,000 each. A committee reviewed the proposals and chose two winning projects.

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The Projects 

One of the projects is for diagnosing drug dependence in newborns while the second is for discovering anti-ALS medicines. 

The first project could help doctors diagnose a increasingly common condition among newborns called Neonatal Abstinence Syndrome (NAS). The syndrome is the withdrawal symptoms that accompany some babies born to a mother with an opioid addiction, such as to prescription pain medications. 

Developed by psychiatry and human behavior and pediatric faculty members Barry Lester and Stephen Sheinkopf and Professor of Engineering Harry Silverman, a computer algorithm that analyzes baby cries could make diagnosis more systematic and reliable.

The second project is a fruit fly model of the neurodegenerative disease amyloid lateral sclerosis. 

The lab of Robert Reenan, professor of biology, has engineered ALS-causing genetic mutations in the flies and used that to discover further mutations in a “suppressor gene” that mitigates the harmful effects of the disease.

The team will use that information to guide a search for “small molecule” compounds that can pharmacologically achieve similarly beneficial effects in the ALS flies.


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